The HIV-1 Accessory Protein Vpu Downregulates Peroxisome Biogenesis
نویسندگان
چکیده
منابع مشابه
Sequences in gibbon ape leukemia virus envelope that confer sensitivity to HIV-1 accessory protein Vpu.
HIV-1 efficiently forms pseudotyped particles with many gammaretrovirus glycoproteins, such as Friend murine leukemia virus (F-MLV) Env, but not with the related gibbon ape leukemia virus (GaLV) Env or with a chimeric F-MLV Env with a GaLV cytoplasmic tail domain (CTD). This incompatibility is modulated by the HIV-1 accessory protein Vpu. Because the GaLV Env CTD does not resemble tetherin or C...
متن کاملVpu Protein: The Viroporin Encoded by HIV-1
Viral protein U (Vpu) is a lentiviral viroporin encoded by human immunodeficiency virus type 1 (HIV-1) and some simian immunodeficiency virus (SIV) strains. This small protein of 81 amino acids contains a single transmembrane domain that allows for supramolecular organization via homoligomerization or interaction with other proteins. The topology and trafficking of Vpu through subcellular compa...
متن کاملHIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes.
Bone marrow stromal antigen 2 (BST-2, also known as tetherin) is a recently identified interferon-inducible host restriction factor that can block the production of enveloped viruses by trapping virus particles at the cell surface. This antiviral effect is counteracted by the human immunodeficiency virus type 1 (HIV-1) accessory protein viral protein U (Vpu). Here we show that HIV-1 Vpu physica...
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The biogenesis of peroxisomal matrix and membrane proteins is substantially different from the biogenesis of proteins of other subcellular compartments, such as mitochondria and chloroplasts, that are of endosymbiotic origin. Proteins are targeted to the peroxisome matrix through interactions between specific targeting sequences and receptor proteins, followed by protein translocation across th...
متن کاملStructure and Function of HIV-1 Vpu
Aside from the typical retroviral gag, pol, and env genes, HIV encodes a series of accessory genes, vif, vpr, vpx, vpu, and nef. The vpu gene is found exclusively in HIV-1 (Strebel et al., 1988; Cohen et al, 1988; Matsuda, 1988). In tissue culture systems, defects in accessory genes are frequently not correlated with a detectable impairment of virus replication and, as a result, these genes are...
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ژورنال
عنوان ژورنال: mBio
سال: 2020
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.03395-19